Simon Lebaron

The paper shows CDC25B promotes spinal cord neurogenesis by coordinating cell cycle progression with ribosome biogenesis, leading to increased translation in differentiating neurons.

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

This study identifies snR37 as a bifunctional H/ACA snoRNP that both pseudouridylates rRNA and scaffolds ribosome assembly during pre-60S intermediate formation.

The paper shows that premature termination of transcription by RNA polymerase I limits rRNA production and that a mutant polymerase, SuperPol, reduces this termination, increasing rRNA output.

The paper investigates Eml1 mutations in mice, finding altered organelle distribution and translation defects in radial glia cells, contributing to subcortical heterotopia.

The paper identifies SURF2 as a MDM2 antagonist that modulates nucleolar stress responses by buffering free-5S RNP particles, linking it to cancer resistance and patient survival.

The paper identifies a dual key lock mechanism involving RIO1 and RPS26 that controls the final maturation step of 40S ribosomal subunits by displacing DIM2 and enabling NOB1-mediated cleavage of 18S rRNA.