Paulo E. Santo

This paper identifies a novel role for the R2T complex in early box H/ACA snoRNP maturation by characterizing interactions between SHQ1, RuvBL1:RuvBL2, and other factors.

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

This study investigates the 3D structure and function of the human R2SP complex using biochemical and structural methods, revealing similarities to the canonical R2TP complex and differences in ATPase activity and adaptor binding.

The paper identifies SURF2 as a MDM2 antagonist that modulates nucleolar stress responses by buffering free-5S RNP particles, linking it to cancer resistance and patient survival.