Cancer BiologyBritish Journal of CancerPeer-reviewed
Attenuation of the CpG Island Methylator Phenotype and lack of WNT signaling activation restrains Kras mutant intestinal neoplasia
Lochlan Fennell, Cheng Liu, Alexandra M. Kane…·Vicki Whitehall
This study compares Kras and Braf mutant intestinal neoplasia in mice, showing Kras mutations lead to less aggressive serrated lesions with reduced WNT signaling activation and attenuated DNA methylation changes compared to Braf mutations.
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