Author

Alexandra M. Kane

Queensland HealthORCID 0000-0002-3414-8455Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Barbara LeggettiD· 2 shared Catherine BondiD· 2 shared Diane McKeone· 2 shared Lochlan FennelliD· 2 shared Vicki WhitehalliD· 2 shared Ann‐Marie PatchiD· 1 shared Cheng LiuiD· 1 shared Günter HärteliD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Barbara LeggettORCID

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2 papers

Recent·Most cited

Cancer BiologyBritish Journal of CancerPeer-reviewedFeb 23, 2026

Attenuation of the CpG Island Methylator Phenotype and lack of WNT signaling activation restrains Kras mutant intestinal neoplasia

Lochlan Fennell, Cheng Liu, Alexandra M. Kane…·Vicki Whitehall

This study compares Kras and Braf mutant intestinal neoplasia in mice, showing Kras mutations lead to less aggressive serrated lesions with reduced WNT signaling activation and attenuated DNA methylation changes compared to Braf mutations.

1 citation

mouseDNA methylation

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GenomicsbioRxivPreprintMar 7, 2022

Comparative analysis of the Illumina Mouse Methylation BeadChip and Reduced Representation Bisulphite Sequencing for routine DNA methylation analysis of murine samples

Lochlan Fennell, Günter Härtel, Diane McKeone…·Vicki Whitehall

The paper compares DNA methylation analysis using the Mouse Methylation BeadChip and reduced representation bisulphite sequencing in murine colorectal carcinogenesis models, showing similar differential methylation detection with different coverage efficiencies.

DOI 10.1101/2022.03.07.483250

mouseDNA methylation

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