Rob Lavigne

This study links genomic diversity to phenotypic virulence in Pseudomonas aeruginosa by analyzing multiple strains and their functional behaviors.

This study identifies a dUTPase from Mosigvirus AV110 that inhibits E. coli growth by disrupting DNA replication and cell division, revealing functional and evolutionary diversity among phage-encoded dUTP/dCTPases.

This study identifies Htm, a phage-encoded protein that reprograms the transcriptome of ESBL-E. coli to support phage replication by altering gene expression and metabolic pathways.

The paper identifies an antibacterial peptide from a phage that inhibits E. coli growth by disrupting Mre-dependent peptidoglycan synthesis.

This study uses high-resolution transcriptomics to reveal complex transcriptional architecture in the archaeal virus SSV1, including new transcription start and termination sites and antisense RNAs.

The paper identifies a high-risk Klebsiella pneumoniae clone with a hybrid virulence-resistance plasmid that spreads during the Ukraine conflict and is vulnerable to lytic phages.

This study identifies distinct viral communities in HS patients compared to controls, highlighting differences in phage composition and potential roles in disease progression.

This study uses structure-informed methods to annotate hypothetical proteins from Pseudomonas phages, showing that combining structural and sequence-based approaches can annotate up to 43% of previously unannotated proteins.

This study shows Ackermannviridae phages can acquire new tail spike proteins to expand their branched receptor complex, enabling adaptation to new hosts.

The paper identifies and characterizes two RNA polymerases in a thermophilic virus, showing their structural and functional differences and evolutionary origin.

This study uses ONT-cappable-seq to map transcriptional landscapes of six Pseudomonas aeruginosa phages, revealing new regulatory elements and gene expression mechanisms.

This paper introduces a CRISPR-Cas3-based genome engineering system for Pseudomonas species that enables efficient genomic integration and vector curing.

This study analyzes the microbial community shifts in HS lesions compared to healthy skin, identifying bacterial imbalances and opportunistic pathogens associated with disease progression.

This paper introduces a bioluminescence-based ex vivo burn wound model to assess antibacterial compounds in real-time, validated with an engineered lysin.

The paper develops ONT-cappable-seq to study phage transcription in Pseudomonas aeruginosa, revealing transcription start sites, terminators, and operon structures in LUZ7.

This paper uses Grad-seq to identify RNA-protein complexes in Pseudomonas aeruginosa under standard and bacteriophage infection conditions, revealing new insights into RNA regulation and phage-host interactions.

This study analyzes Pseudomonas aeruginosa virus PA5oct using hybrid sequencing and proteomics to reveal its genomic structure, transcription dynamics, and interactions with host bacteria.

The paper analyzes the genome, transcriptome, and proteome of Pseudomonas virus PA5oct to uncover its molecular complexity and gene regulation patterns.

The paper identifies a conserved bacterial adaptive phage response (BAPR) through comparative transcriptomics in Pseudomonas aeruginosa infected by bacteriophages.