Wesley P. Wong

The paper introduces a DNA nanoswitch calipers platform to simultaneously measure structural and mechanical properties of biomolecules, demonstrating its application on telomeric DNA G-quadruplexes.

This paper introduces a light-guided surface patterning method for organizing oligonucleotides, enabling precise control and high-throughput single-molecule experiments.

This paper introduces a high-throughput centrifuge force microscope to quantify single-cell immune interactions, revealing receptor-specific binding dynamics and time-dependent avidity changes in BiTE-mediated T-cell binding.

The paper introduces a method to map 3D geometries of single-molecule protein complexes with high resolution using DNA Nanoswitch Calipers and force-based barcoding, achieving agreement with known structures.