Vishawjeet Barik

This study shows that limiting sulfur availability in Mycobacterium tuberculosis increases its vulnerability to antibiotics and enhances drug efficacy in a mouse model.

This study shows that phosphoglucomutase A (pgmA) is essential for Mycobacterium tuberculosis survival under nutrient-limiting conditions and disease persistence.

This study shows that the direct sulfhydrylation pathway in Mycobacterium tuberculosis is essential for growth at low pH and modulates BDQ sensitivity.

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

This study designs triazole inhibitors targeting M. tuberculosis's histidine biosynthesis pathway, showing efficacy against drug-resistant strains and reducing bacterial burden in infected mice.