Author

Karol Fiedorczuk

Rockefeller UniversityORCID 0000-0001-7439-0222Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Jue CheniD· 2 shared András SzöllősiiD· 1 shared Csaba MihályiiD· 1 shared I. IordanoviD· 1 shared Jesper LevringiD· 1 shared László CsanádyiD· 1 shared Paul G. YoungiD· 1 shared Scott C. BlanchardiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Jue ChenORCID

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2 papers

Recent·Most cited

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedNov 4, 2024

The structures of protein kinase A in complex with CFTR: mechanisms of phosphorylation and reversible activation

Karol Fiedorczuk, I. Iordanov, Csaba Mihályi…·Jue Chen

This study presents cryo-EM structures of PKA-C bound to CFTR, revealing mechanisms of phosphorylation and reversible activation through catalytic interactions and conformational flexibility.

27 citationstop 2%

humanprotein structure

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedFeb 29, 2024

Structural basis for CFTR inhibition by CFTRinh-172

Paul G. Young, Jesper Levring, Karol Fiedorczuk…·Jue Chen

This paper determines the structure of CFTR bound to CFTRinh-172 using cryo-EM, revealing its dual role as a pore blocker and gating modulator.

22 citationstop 3%

humancryo-EM

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