Chen‐Yi Liao

This paper presents a framework to optimize agent-based models using spatial data by comparing imaging data and model outputs in a shared latent space, showing improved reproduction of spatial features.

The paper develops a high-throughput 3D ECM remodeling assay to identify MEK as a key driver of fibrotic fibroblast activity, showing that MEK-ERK signaling, not TGFβ signaling, drives ECM remodeling.

This study identifies ROPN1 as a target for TCR-engineered T-cells effective against TNBC in preclinical models and demonstrates their safety and efficacy.