Erik H.J. Danen

This study shows that SEPT7 depletion reduces breast cancer cell invasion in 3D collagen gels by affecting actin-based protrusions and cell shape.

This paper presents a framework to optimize agent-based models using spatial data by comparing imaging data and model outputs in a shared latent space, showing improved reproduction of spatial features.

This study identifies metabolic targets in breast cancer by analyzing multi-omics data from cell lines, revealing subtype-specific dependencies and potential drug targets.

This study combines experimental and computational approaches to understand how cell-cell and cell-matrix interactions influence cancer cell invasion and metastasis.

This paper introduces a method to measure cellular traction forces in 3D tumoroid cultures using elastic microparticles, revealing cellular stress ranges and interactions with the extracellular matrix.

This study investigates how matrix stiffness influences spheroid invasion, collagen remodeling, and stress propagation in the ECM using 3D spheroids and stress sensors.

The paper develops a high-throughput 3D ECM remodeling assay to identify MEK as a key driver of fibrotic fibroblast activity, showing that MEK-ERK signaling, not TGFβ signaling, drives ECM remodeling.

This study investigates altered mechanobiology in PDAC cells with acquired chemoresistance to gemcitabine and paclitaxel, finding increased traction forces and altered motility and invasion.

This study identifies ROPN1 as a target for TCR-engineered T-cells effective against TNBC in preclinical models and demonstrates their safety and efficacy.