Isac Lee

The paper introduces a method to detect protein-DNA binding in single molecules using antibody-guided methylation, generating identifiable methylation patterns near binding sites.

This study identifies 504 plasma proteins influenced by HLA genetic variation in 45,330 Europeans, revealing their roles in immune function and disease.

This study introduces nanoNOMe, a method combining NOMe-seq and nanopore sequencing to profile chromatin accessibility and methylation in human cell lines, revealing phased methylation, large-scale patterns, and structural variations.

This study uses long-read sequencing to identify structural variants in breast cancer genomes, showing high accuracy and sensitivity compared to short-read methods.

The paper introduces a targeted nanopore sequencing method using Cas9 to profile methylation, structural variants, and mutations in cancer-related genes with high coverage and low cost.