Daniel Zvi Bar

The paper tests whether DNA damage drives aging by analyzing cell-identity DNA methylation changes in human fibroblasts and finds that division history, not DNA damage, correlates with loss of identity information.

The paper develops colon-specific epigenetic clocks using minimal CpG sites to predict age and reveal disease-driven aging in the colon.

The paper develops cell-permeable C16orf74 peptides that disrupt Calcineurin-NFAT interaction, inhibit T-cell activation, and show minimal cytotoxicity compared to Cyclosporine A.

This paper shows that liver-specific methylation sites regress toward a pan-tissue average during aging and disease, and this loss can be partially reversed by fasting.

The paper shows that epigenetic information loss, characterized by degradation of tissue-unique methylation patterns, occurs in multiple diseases and aging.

The paper introduces a method to detect protein-DNA binding in single molecules using antibody-guided methylation, generating identifiable methylation patterns near binding sites.

This study evaluates psoriasin's ability to inhibit Candida albicans growth on denture bases, finding it effectively eradicates fungal growth when applied to the material.

The paper identifies kidney-specific methylation patterns that correlate with kidney function and show changes during disease progression.

This paper calibrates a mass spectrometry protocol for extracting and analyzing proteins from dental calculus, showing that acetic acid, crushing, and sonication maximize yield while acetone precipitation enhances protein identification.

This paper introduces a proximity labeling method using antibodies to detect protein interactions in fixed cells and tissues, revealing tissue-specific variations in the nuclear envelope and altered interactions under stress.