Darren J. Creek

The paper identifies potent reaction hijacking inhibitors targeting Plasmodium falciparum asparagine tRNA synthetase, showing high selectivity and resistance refractoriness.

This study identifies MMV687794 as an inhibitor of Plasmodium falciparum RBC invasion by targeting PfSLIRP, a rhoptry protein involved in lipid metabolism and vacuole formation.

This study uses metabolomics to analyze how two CLOs disrupt MRSA membranes, revealing distinct metabolic changes that indicate membrane destabilization and lipid remodeling.

This study validates solvent proteome profiling (SPP) as a method to identify antimalarial drug targets in Plasmodium falciparum by detecting ligand-induced protein stability changes.

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

This study investigates the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum by combining chemoproteomic methods and genetic validation.

The paper validates repurposed drugs against SARS-CoV-2 using stem cell-derived cardiomyocyte and nasal epithelium models, confirming fluvoxamine's antiviral efficacy in combination with other drugs.

This paper identifies MMV1557817 as a dual aminopeptidase inhibitor effective against multiple Plasmodium species and highlights its potential as a multi-target antimalarial drug.

This study shows that dietary fibre and SCFA supplementation improve post-stroke outcomes in mice by modulating the gut microbiome and acting through GPR41/43/109A receptors.

This study shows dietary fiber lowers blood pressure by reducing large intestinal pH and activating GPR65 in CD8+ T cells, which reduces inflammation and hypertension-related damage.