Author

Andy A. Garcia

Stanford UniversityORCID 0000-0001-7515-5646Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:gene regulatory network inference· 1 Organism:multiple species· 1

Frequent Co-Authors

Paula V. WelanderiD· 4 shared Friedhelm PfeifferiD· 2 shared Grayson L. ChadwickiD· 2 shared Mechthild PohlschröderiD· 2 shared Yirui HongiD· 2 shared Dipti D. NayakiD· 1 shared Jacob A. CoteiD· 1 shared Kira S. MakarovaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

Paula V. WelanderORCID

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4 papers

Recent·Most cited

Molecular BiologyJournal of Biological ChemistryPeer-reviewedAug 25, 2026

Characterization of aliA and aliB deletion mutants reveals a dominant role of AliA in Haloferax volcanii lipoprotein lipidation

Yirui Hong, Andy A. Garcia, Samuel Kopelev…·Mechthild Pohlschröder

DOI 10.1016/j.jbc.2026.113477

proteomicsexperimental assay

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MicrobiologybioRxivPreprintOct 20, 2025

Identification of radical SAM enzymes responsible for the methylation and desaturation of archaeal lipids and an AttH hydratase mediating hydroxy-GDGT biosynthesis

Andy A. Garcia, Grayson L. Chadwick, Dipti D. Nayak, Paula V. Welander

This paper identifies novel radical SAM enzymes involved in archaeal lipid methylation, desaturation, and hydroxy-GDGT biosynthesis using three archaeal species.

2 citations

C. elegansexperimental assay

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MicrobiologyNature CommunicationsPeer-reviewedSep 25, 2025

Beyond bacterial paradigms: uncovering the functional significance and first biogenesis machinery of archaeal lipoproteins

Yirui Hong, Kira S. Makarova, Andy A. Garcia…·Mechthild Pohlschröder

The paper identifies and characterizes archaeal lipoprotein biogenesis components, showing their essential role in archaeal cell physiology and revealing distinct enzymatic activities.

5 citations

multiple speciesproteomics

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MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedJun 17, 2024

Discovery of two archaeal GDGT lipid modifying enzymes reveals diverse microbes capable of H-GDGT biosynthesis and modification

Andy A. Garcia, Grayson L. Chadwick, Xiao‐Lei Liu, Paula V. Welander

This paper identifies two archaeal enzymes involved in H-GDGT lipid modifications and demonstrates their role in producing diverse H-GDGT structures under different environmental conditions.

29 citations

experimental assay

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