Jesús María Paramio

This study develops genetically engineered mouse models of advanced bladder cancer to investigate cell-of-origin and driver mutations, revealing subtype-specific characteristics and therapeutic responses.

This study identifies GRK2's role in hair follicle homeostasis by showing its deletion leads to cyst formation, stem cell disruption, and hair loss in mice.

This study identifies CD44v6 as a driver of bladder cancer aggressiveness and chemoresistance, linking its expression to poor patient outcomes and therapeutic resistance.

This study identifies mutation patterns, TMB, HLA haplotypes, and LINE-1 activation as potential biomarkers for predicting ICI response in NSCLC and MIBC.

The paper analyzes the tumor microenvironment of NMIBC, finding that cancer-associated myofibroblasts are prognostic markers for progression and recurrence.

The paper clusters head and neck squamous cell carcinomas based on lncRNA expression and identifies molecular and clinical associations.