Toshio Suda

This study identifies BRM as a critical regulator of bone marrow sinusoidal niche integrity and hematopoietic regeneration, showing that its decline with age contributes to niche dysfunction and hematopoietic aging.

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

This study shows that THPO protects HSCs from inflammatory stress by maintaining membrane lipid integrity and suppressing STAT1-driven pyroptosis.

This study tracks Gfi1 expression dynamics during hematopoietic development and identifies its role in defining EHT and HSC potency.

The paper develops a DNA barcoding-based method to analyze HSC daughter cell pairs, revealing biased division patterns toward symmetric divisions and linking these to molecular features.

This study identifies Plcl1 as a regulator of calcium dynamics in hematopoietic stem cells, affecting their function during aging and stress.

This paper develops a system to predict hematopoietic stem cell diversity using quantitative phase imaging and machine learning, capturing temporal kinetics rather than single snapshots.

This study shows JMJD3 promotes senescence in HSPCs to overcome stress-induced hematopoietic defects, with implications for aging and cancer therapies.

The paper describes a two-photon photothrombosis protocol to induce depth-targeted single vessel thrombosis in rodent brains with high success rate.

This study uses single-cell profiling and deep learning to show that hematopoietic stem cell self-renewal declines with age due to stochastic division patterns and prior division history.