Author

Jia-Shiun Leu

Houston MethodistORCID 0000-0001-7557-3362Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Han Nhat Tran· 3 shared Kyuson YuniD· 3 shared Nourhan H AbdelfattahiD· 3 shared Fransisca LeonardiD· 2 shared Jose Maldonado· 2 shared Ningyan ZhangiD· 2 shared Reece Kang· 2 shared Thomas K. S. Wong· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Han Nhat Tran

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 12, 2026

S100A4 Is a Targetable Regulator of Immune Suppression in Glioblastoma

Thomas Wong, Jia-Shiun Leu, Maryam Faisal…·Kyuson Yun

This study identifies S100A4 as a targetable regulator of immune suppression in glioblastoma, showing its inhibition enhances immunotherapy response and survival.

DOI 10.64898/2026.11.10.765528

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 3, 2026

Ex vivo human tumor slices more accurately predict patient responses to an oncolytic virus than in vivo mouse models

Jose Maldonado, Thomas K. S. Wong, Jia-Shiun Leu…·Kyuson Yun

This study shows that human tumor slices better predict patient responses to an oncolytic virus than mouse models, highlighting indication-specific efficacy.

DOI 10.64898/2026.09.01.748437

humanmouse

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Cancer BiologyCancer LettersPeer-reviewedApr 8, 2026

Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis to the lung by activating T and NK cells

Jia-Shiun Leu, Hui Deng, Han Nhat Tran…·Kyuson Yun

This study shows that combining S100A4 and TIGIT inhibition suppresses breast cancer lung metastasis by enhancing T and NK cell activity in late-stage disease.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky