Martin Fuhrmann

This paper develops a method for correcting geometric drift and reconstructing identities in 3D time-lapse point cloud data using synthetic and biological datasets.

This paper shows that inhibitory plasticity in competitive spiking networks requires a matched inhibitory budget to maintain stability and performance, unlike fixed inhibition.

The paper introduces ic-analysis, an open-source toolkit for standardized IntelliCage behavioral analysis, demonstrating its ability to recover behavioral differences in a synthetic experiment.

ZenReg is a Python platform for N-dimensional microscopy image registration that improves motion correction accuracy and efficiency in biological data.

The paper introduces a Python package for reproducible spectral unmixing in microscopy data, demonstrating improvements in bleed-through correction across different unmixing methods.

OMIO provides a policy-driven Python library to standardize microscopy image I/O, ensuring reproducible and interoperable data handling across formats and workflows.

This paper develops an endothelial graft-enhanced CAM tumor model to study T cell recruitment and activation in human cancer immunotherapy.

The paper introduces PinkyCaMP, a new red fluorescent calcium sensor with improved brightness, photostability, and compatibility with optogenetics and neurotransmitter imaging.

This study uses three-photon imaging to examine microglia-glioblastoma interactions in a mouse model, revealing a biphasic response and directional movement of microglia toward tumor cells.

MotilA quantifies microglial fine process motility in 3D time-lapse microscopy data using a pixel-based change detection strategy, providing biologically interpretable metrics like turnover rate.

This study identifies molecular factors shaping brain-resident CD8+ T cell formation and function in health and disease.

This paper demonstrates three-photon in vivo imaging in the mouse medial prefrontal cortex to achieve sub-cellular resolution of neuronal and glial activity at unprecedented depths.

This study shows that ADF/Cfl1 deficiency in microglia reduces motility and impairs memory by affecting cytoskeleton dynamics.

This study shows that CX3CR1 deficiency enhances microglial migration towards brain injury, suggesting it as a potential therapeutic target for CNS injuries.

The paper reports that common AAV transduction procedures can induce artefactual Ca2+ micro-waves in the hippocampus and provides an alternative method to avoid this issue.

This study shows that microglia motility depends on neuronal activity and promotes synaptic plasticity in the hippocampus of awake mice.

The paper introduces sDarken, a new family of genetically encoded serotonin sensors, demonstrating their effectiveness in imaging serotonin dynamics with high resolution.

This study shows that elevated C4 expression in the mouse prefrontal cortex causes schizophrenia-like phenotypes including synaptic and cognitive deficits.

The paper investigates hippocampal neuronal activity in a rat Alzheimer's disease model, finding hyperactivity and intrinsic excitability changes in CA1 neurons before synaptic inhibition is affected.

This study shows that HDB projections to the olfactory bulb modulate odor-evoked responses and are critical for olfactory-mediated habituation and discrimination behaviors.

This study uses stimulated Raman scattering microscopy to characterize amyloid-β plaques and associated lipids in AD mouse brain tissue, revealing structural and compositional features of pathological deposits.

The paper shows that in a mouse model of AD, memory recall is impaired due to the superimposition of new neurons onto the memory trace during retrieval.

The paper restores memory in Alzheimer’s disease mice by optogenetically synchronizing hippocampal theta oscillations.