Author

Aoi Akitsu

Harvard UniversityORCID 0000-0001-7672-9664Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:scRNA-seq· 1 Assay:structural biology· 1

Frequent Co-Authors

Ellis L. ReinherziD· 3 shared Matthew J. LangiD· 3 shared Robert J. MallisiD· 3 shared Wonmuk HwangiD· 3 shared Evan H. KirkpatrickiD· 2 shared Jonathan S. Duke‐CohaniD· 2 shared Kristine N. BraziniD· 2 shared Matthew Aaron BookeriD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Ellis L. ReinherzORCID

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3 papers

Recent·Most cited

ImmunologyThe Journal of ImmunologyPeer-reviewedJul 28, 2026

Atomistic TCR-ligand interactions shape memory T-cell differentiation

Aoi Akitsu, Kemin Tan, Robert J. Mallis…·Ellis L. Reinherz

The paper identifies how TCR-ligand interactions influence memory T-cell differentiation by analyzing clonotype-specific signaling and functional outcomes.

DOI 10.1093/jimmun/vkag141.1794

mousescRNA-seq

𝕏 PostBluesky

BiophysicseLifePeer-reviewedApr 7, 2025

Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

Ana Cristina Chang-Gonzalez, Aoi Akitsu, Robert J. Mallis…·Wonmuk Hwang

The paper compares the mechanical behavior of two TCRs recognizing the same pMHC using MD simulations, showing differences in load response due to dynamic allostery.

4 citations

structural biologybiophysical modeling

𝕏 PostBluesky

ImmunologyScience AdvancesPeer-reviewedAug 14, 2024

Parsing digital or analogue TCR performance through piconewton forces

Aoi Akitsu, Eiji Kobayashi, Yinnian Feng…·Ellis L. Reinherz

The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.

22 citations

mouseexperimental assay

𝕏 PostBluesky