Author
Kyoto UniversityORCID 0000-0001-7678-4284Unclaimed ORCID profile · follow to get notified of new preprints
11 papers
Recent·Most cited
Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya…·Seishi Ogawa
This study identifies 16 AML subgroups based on chromatin accessibility profiles using ATAC-seq in 1,563 cases, revealing epigenetic heterogeneity and its clinical and therapeutic implications.
Yoshimasa Adachi, Mitsuhiro Sugimoto, Yusei Yamada…·Tomohiro Terada
The paper identifies a pharmacokinetic interaction between teicoplanin and SBECD, an excipient in posaconazole, showing reduced TEIC protein binding and increased renal excretion in rats and patients.
Shuhei Tsujino, Masumi Tsuda, Sayaka Deguchi…·Miki Kawano
This study identifies the non-spike R204P mutation in the SARS-CoV-2 Omicron XEC variant as a driver of increased inflammation and pathogenicity through NF-κB activation.
Shinichiro Oshima, Rahul Sinha, Kazuhiro Takeuchi…·Ryō Yamamoto
The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.
Katsuyuki Nishi, Taro Sakamaki, Akiomi Nagasaka…·Masanori Miyanishi
The paper shows that myeloid-biased hematopoiesis in aging is due to altered LT-HSC/ST-HSC ratios, not HSC clone heterogeneity.
Yusuke Kosugi, Arnon Plianchaisuk, Olivia Putri…·Kei Sato
This study investigates the virological properties of the SARS-CoV-2 HK.3 variant, a FLip variant with substitutions S:L455F and S:F456L, to assess its growth advantage.
Yusuke Kosugi, Yu Kaku, Alfredo A. Hinay…·Kei Sato
The paper assesses the humoral immune response to XBB.1.5 vaccine in infection-naive and XBB-infected individuals against various SARS-CoV-2 variants.
Ryota Maeda, Junso Fujita, Yoshinobu Konishi…·Akifumi Takaori‐Kondo
The paper presents nine alpaca nanobodies that recognize conserved hidden epitopes on SARS-CoV-2 spike proteins across variants and maintain neutralizing activity against escape mutations.
Fumiya Moribe, Momoko Nishikori, Tsuyoshi Takashima…·Junko Murai
The paper examines SLFN11 expression in B-cell development and lymphomas, finding it is epigenetically suppressed in germinal center B cells and that epigenetic modifiers enhance its expression, increasing sensitivity to cytosine arabinoside.
Elsa Bernard, Yasuhito Nannya, Robert Paul Hasserjian…·Elli Papaemmanuil
The paper examines TP53 allelic states in MDS patients, finding that bi-allelic targeting is linked to worse outcomes, while mono-allelic targeting does not differ from wild-type patients.
Shigeki Hirabayashi, Shruti Bhagat, Yu Matsuki…·Yasuhiro Murakawa
The paper develops NET-CAGE to detect nascent RNA 5-ends, identifies enhancer-promoter pairs, and reveals topological connections of cis-regulatory elements across cell types.