Author

Antonio Casini

ORCID 0000-0001-7709-4955Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:long-read sequencing· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Anna CeresetoiD· 2 shared Eyemen KheiriD· 2 shared Giulia Vittoria Ruta· 2 shared Matteo CicianiiD· 2 shared Michele Domenico Gentile· 2 shared Alessio ConciiD· 1 shared Chiara Valentini· 1 shared Daniele Menghini· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioengineering

Anna CeresetoORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintAug 17, 2026

Enhancing hypercompact Cas{Phi}2 activity through EPICA.2, an optimized eukaryotic directed evolution platform

Giulia Vittoria Ruta, Matteo Ciciani, Veronica De Sanctis…·Anna Cereseto

The paper enhances Cas{Phi}2 activity using EPICA.2, an optimized directed evolution platform, resulting in evoCas{Phi}2 with 70-fold increased activity in human cells.

DOI 10.64898/2026.08.12.744198

humanlong-read sequencing

𝕏 PostBluesky

BioengineeringGenome biologyPeer-reviewedMar 25, 2024

Eukaryotic-driven directed evolution of Cas9 nucleases

Giulia Vittoria Ruta, Matteo Ciciani, Eyemen Kheir…·Anna Cereseto

This study enhances weakly active Cas9 nucleases using a eukaryotic platform, resulting in a 12-fold increase in activity in mammalian cells while maintaining specificity.

16 citations

yeastmouse

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