Joshua W. Modell

The paper demonstrates engineered phages can evade multiple defense systems in MRSA strains, preventing resistance emergence and offering a strategy for next-generation phage therapy.

The paper identifies a dynamic subpopulation of CRISPR-Cas overexpressers in Streptococcus pyogenes that enhance phage defense but reduce fitness in the absence of phage.

The paper shows anti-CRISPR proteins in S. pyogenes reduce Cas9 autorepression, leading to increased CRISPR-Cas expression and enhanced phage defense.