Masashi Narita

The paper identifies Eda2r as a key mediator in both developmental and pathological senescence by profiling senescent cells in mouse limb development and comparing them to in vitro and in vivo models.

This study shows that oncogenic HRAS-induced senescence in human fibroblasts involves enhancer-promoter rewiring and dynamic cohesin binding, particularly at SASP genes.

This study shows increased lamin B1 levels in HD neurons disrupt nuclear function, and reducing lamin B1 with betulinic acid improves nuclear homeostasis and prevents motor and cognitive dysfunction in a mouse model.

This study shows that inhibiting autophagy in mammals accelerates aging and increases cancer risk, while restoring autophagy extends lifespan but does not fully prevent cancer.