Karl Herrup

This study identifies nuclear BIN1 isoforms in oligodendrocytes and shows their role in regulating c-Myc-mediated cell cycle control, linking BIN1 dysregulation to myelin pathology in Alzheimer's disease.

The paper shows that DNA damage increases with age and correlates with higher APP levels in Alzheimer's disease, suggesting DNA damage drives APP accumulation.

This study shows that APP overexpression and Aβ exposure affect neural activity differently in immature and mature cultures, suggesting distinct roles in Alzheimer's disease mechanisms.

The paper identifies TRIM47 as a genetic risk factor for white matter hyperintensity and shows it inhibits autophagy in brain endothelial cells.

The paper examines DNA damage and senescence in Alzheimer's disease cortex and finds they are increased and coupled in AD but not in controls.

This study identifies lncMtDloop as a regulator of mitochondrial homeostasis, showing reduced expression in AD and improved pathology with its overexpression.

The paper compares the stress-reducing effects of two Japanese gardens by measuring physiological responses and eye movement patterns.

This study investigates how cuprizone-induced demyelination affects two Alzheimer's disease mouse models, finding that myelin loss precedes amyloid deposition and may drive pathology.

This paper shows that full-length APP affects axon initial segment structure, linking APP function to Alzheimer's disease without relying on Aβ.

The paper evaluates methods for accurately classifying RNA sequencing reads from mixed-species data, finding alignment-dependent and alignment-independent approaches effective across different species ratios.

The paper shows that ATP depletion causes oxidative stress, activates ATM, which phosphorylates NRF1 to enhance mitochondrial function, and that ATM deficiency impairs ATP recovery in energy-demanding cells.