Huimei Chen

This study uses spatial transcriptomics to identify disease-responsive compartments and immune-fibrotic signaling in AAV kidney biopsies, linking them to histopathology and fibrotic injury.

The paper identifies parvalbumin interneurons in the temporal lobe as highly vulnerable to genetic risk factors and psychoactive drugs in neuropsychiatric disorders.

This study compares scRNA-seq methods with and without sample multiplexing, showing Parse detects rare cell types better despite lower efficiency, while 10X has platform-specific gene length and GC content distributions.

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.