Avery J. Lam

This study investigates how cell cycle dynamics influence T cell fate and exhaustion by analyzing single-cell data and manipulating cell cycle progression and signaling.

The paper defines human HSPC subsets and differentiation trajectories using surface proteins and functional regulators, validated by epigenetic analysis and clonal assays.

This study engineers CAR Tregs to secrete IL-10 via PDCD1-driven regulation, enhancing their suppressive function in vitro and in vivo.

The paper describes a germline variant in IKZF2 causing immune dysregulation, including AIHA and atopic dermatitis, and reports single-cell RNA sequencing findings on T cell dysfunction.