Swetha Ramesh

This study detects pervasive cryptic negative selection in human noncoding regions using a statistical test, finding that at least 7% of the genome is under negative selection, surpassing previous estimates from conservation-based methods.

The paper infers the fitness effects of noncoding mutations in humans using genomic annotations and polymorphism data, finding distinct selection patterns across different noncoding regions.

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

This paper describes engineering a fluorine-selective enzyme to produce fluorinated polyketide analogs using E. coli.