Neal Patrick Smith

The paper identifies a cDC2-Treg feedback circuit in barrier tissues that limits Th2 cell expansion during allergic inflammation.

This study compares T cell phenotypes and clonotypes from bronchoalveolar lavage and endobronchial brushings in healthy controls and allergic asthmatics, finding distinct transcriptional and TCR repertoire features.

This study identifies a novel CD8+ TIL subset that uses lymphotoxin and IFN pathways to kill cancer cells, linking LTB expression to clinical response in melanoma.

The paper identifies a sensory neuron-intrinsic mTORC1 signaling mechanism that establishes neuroimmune memory, enhancing allergic immunity upon allergen re-exposure.

This study identifies AP-1 transcription factors as key regulators of TRM development across tissues using scRNA-seq and ATAC-seq, revealing a novel mechanism for TRM reactivation.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

The paper analyzes 6 million T cells from 91 studies to identify TCR sequence convergence patterns and their association with functional and cellular T cell phenotypes.

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.