Hongen Xu

This paper introduces a high-accuracy CRISPR array assembly strategy that enables efficient assembly of multiple crRNAs in a single reaction, improving the practicality of multiplex CRISPR applications.

This study identifies PKHD1L1 as a cause of autosomal recessive nonsyndromic hearing loss through exome sequencing and functional analysis in human families and animal models.

The paper systematically studies the sensitivity of 74,389 EGFR variants to five tyrosine kinase inhibitors using cytotoxicity assays and presents a comprehensive reference for treatment responses.

The paper investigates ACE2 and TMPRSS2 expression in the inner ear, brain, and muscle of mice and hamsters to assess SARS-CoV-2 infection potential and its link to sensorineural hearing loss in COVID-19.