Shuqing Chen

TRAIT compiles nearly 8 million experimentally validated TCR-antigen pairs to provide a comprehensive resource for T-cell receptor interactions, aiding immunotherapy and vaccine design.

A 'shock-and-lock' nanoparticle agonist activates STING in type 1 conventional dendritic cells to enhance antitumor immunity with associated biomarkers.

DeepTAP predicts TAP-binding peptides using an RNN, outperforming existing methods on benchmark datasets.

Spanve is a nonparametric statistical method that identifies spatially variable genes in spatial transcriptomic data with fewer false positives, enabling better downstream analysis.

TSNAdb v2.0 updates the tumor-specific neoantigen database with stricter identification criteria, predicted neoantigens from three mutation types, and experimentally validated neoantigens classified by evidence.

The paper systematically studies the sensitivity of 74,389 EGFR variants to five tyrosine kinase inhibitors using cytotoxicity assays and presents a comprehensive reference for treatment responses.

The paper predicts potential B/T-cell epitopes for multiple coronaviruses and stores the results in a database for vaccine development.

This paper designs multi-epitope peptide vaccines against SARS-CoV-2 using immunoinformatics, showing they elicit strong humoral and cellular immune responses in mice.