Author

Ellen E. Cho

Loyola University ChicagoORCID 0000-0001-7953-2736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Sean R. ClearyiD· 2 shared Seth L. RobiaiD· 2 shared Allen C. T. TengiD· 1 shared Anthony O. GramoliniiD· 1 shared Audrey Deyawe KongmeneckiD· 1 shared Catherine A. MakarewichiD· 1 shared Himanshu KhandeliaiD· 1 shared Jaroslava ŠeflováiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

Sean R. ClearyORCID

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2 papers

Recent·Most cited

PhysiologyJournal of Biological ChemistryPeer-reviewedDec 21, 2024

Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of cardiac calcium handling

Sean R. Cleary, Allen C. T. Teng, Audrey Deyawe Kongmeneck…·Seth L. Robia

This study shows that the R14del mutation in phospholamban increases pentamer stability, reducing its ability to regulate SERCA and impairing cardiac calcium handling during physiological stress.

14 citations

humanproteomics

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BiochemistrybioRxivPreprintJul 20, 2023

Phospholamban Inhibits the Cardiac Calcium Pump Through Reversing the Allosteric Enhancement of Calcium Affinity by ATP

Sean R. Cleary, Jaroslava Šeflová, Ellen E. Cho…·Seth L. Robia

This paper investigates how phospholamban (PLB) inhibits the cardiac calcium pump SERCA by reversing ATP-induced allosteric enhancement of calcium affinity, using biochemical assays and structural analysis.

DOI 10.1101/2023.07.20.549928

proteomicsexperimental assay

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