Author

Jaroslava Šeflová

Loyola University ChicagoORCID 0000-0001-5486-0864Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Seth L. RobiaiD· 2 shared Carlos Cruz-Cortés· 1 shared Guadalupe Guerrero-Serna· 1 shared Howard S. YoungiD· 1 shared Jacob D. CunninghamiD· 1 shared Jonathan A. KirkiD· 1 shared L. Michel Espinoza-Fonseca· 1 shared Laura A. ShereriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

Seth L. RobiaORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintApr 28, 2026

A Novel Mechanism of Cardiomyopathy: Toxic Peptides Dysregulate Calcium Transport

Taylor A. Phillips, Jacob D. Cunningham, Mary D. Hernando…·Seth L. Robia

The paper identifies toxic transmembrane peptides that inhibit SERCA function in DCM, offering a new mechanism for calcium mishandling in heart failure.

1 citation

humanproteomics

𝕏 PostBluesky

BiophysicsbioRxivPreprintSep 7, 2023

Activation mechanism of the cardiac calcium pump by a small-molecule allosteric modulator

Jaroslava Šeflová, Carlos Cruz-Cortés, Guadalupe Guerrero-Serna…·L. Michel Espinoza-Fonseca

This study uses TCSPC imaging to show that CDN1163, a SERCA2a activator, synergizes with ATP to shift SERCA2a toward a competent conformation, enhancing its function under physiological conditions.

DOI 10.1101/2023.09.07.556734

microscopy & imaging analysisprotein folding & dynamics

𝕏 PostBluesky