Yi‐Wei Chang

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

This study identifies PF3D7_0707400 as an essential ATAD3A ortholog in Plasmodium falciparum, showing its role in mitochondrial processes and parasite survival.

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

This study identifies caspase-1 and GSDMD as key mediators of inflammasome responses that restrict Salmonella replication in human macrophages.

The paper uses cryo-ET to reveal the architecture of centromeric chromatin clearings and their role in kinetochore formation and amplification.

This paper presents a method to image unfixed, never frozen human brain tissue using cryo-ET with xenon plasma FIB milling, revealing native ultrastructures like myelin and autophagy components.

The paper uses electron cryo-tomography to analyze membrane projections and associated protein complexes in bacterial species, identifying diverse structures and protein associations.

DISCA uses deep learning to automatically cluster cryo-ET data into homogeneous structural subsets without templates or labels.