Koei Chin

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

This study shows that interferon gamma restores antigen presentation in medulloblastoma and enhances T cell-mediated tumor killing in a mouse model.

PIVOT is an open-source tool for nonlinear registration of multi-omic spatial data, demonstrating improved throughput compared to existing workflows.

This study shows PIN1 promotes cellular plasticity and immune changes in chronic pancreatitis, with genetic or pharmacological inhibition reducing disease severity.

This study shows HBP1 protects against acute pancreatitis but promotes pancreatic cancer progression in the presence of KRAS mutations.

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.

Galaxy-ME is a web-based software hub for analyzing and visualizing multiplex tissue imaging datasets, demonstrating its utility on normal and cancerous tissue data.

The paper develops open-source tools for analyzing multiplex tissue imaging data and demonstrates their application on a human breast cancer dataset.

RESTORE normalizes intensity variations in multiplexed imaging data by using negative control cells to remove background noise and improve sample integration.

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.