Author

Jorge García Morato

Mayo ClinicORCID 0000-0001-8061-7841Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Dennis W. DicksoniD· 2 shared Wilfried RossolliD· 2 shared Adam N. TrautwigiD· 1 shared Aleksandar Rajkovic· 1 shared Aleksandra V. SergeevaiD· 1 shared Alf HonigmanniD· 1 shared Andrew StrangeiD· 1 shared Anh M. Ly· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Dennis W. DicksonORCID

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2 papers

Recent·Most cited

Cell BiologyCellPeer-reviewedMay 23, 2025

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

Xiao Yan, David Kuster, Priyesh Mohanty…·Anthony A. Hyman

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

183 citationstop 1%

humanproteomics

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NeurosciencebioRxivPreprintApr 20, 2025

TDP-43 toxic gain of function links ALS, FTD and Alzheimers Disease through splicing dysregulation

Welmoed van Zuiden, Thea Deborah Meimoun, Bar Chen…·Eran Hornstein

This study identifies TDP-43-driven splicing dysregulation as a common mechanism in ALS, FTD, and Alzheimer's disease, linking them through mis-spliced mRNAs like APP.

8 citations

humanmetagenomics

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