Maria Łęcka

The paper develops selective chemical probes and antibody-drug conjugates for cathepsin S by profiling substrate specificity with unnatural amino acids and validates their efficacy in cancer models.

This paper introduces a modular CAR-Fab platform that improves cancer immunotherapy by enabling rapid target redirection and reducing antigen loss variant escape.

This study shows ammonia reduces NK cell antitumor activity by decreasing mature perforin levels in the tumor microenvironment.