Marcin Poręba

This study identifies legumain and cathepsin V as key regulators of extracellular matrix remodeling in pulmonary fibrosis, acting together with cystatin M/E to modulate fibronectin and elastin turnover.

The paper develops selective chemical probes and antibody-drug conjugates for cathepsin S by profiling substrate specificity with unnatural amino acids and validates their efficacy in cancer models.

This study identifies glycosaminoglycans as activators of PAD4, showing they enhance Ca2+ affinity and induce NETosis, with implications for rheumatoid arthritis.

This study evaluates the cytotoxicity of 32 essential oils on HaCaT cells, finding 14 oils reduced cell viability below 50%.

This study shows ammonia reduces NK cell antitumor activity by decreasing mature perforin levels in the tumor microenvironment.

This study characterizes CAR+ T-cell subsets and immune system dynamics in pediatric BCP-ALL patients treated with tisagenlecleucel, finding correlations between immune cell changes and cytokine release syndrome.

This study develops covalent caspase inhibitors that block pyroptosis and IL-1β secretion through GSDMD pores, showing therapeutic potential for inflammatory diseases.

This study shows CD20 stabilizes CD37 on B-cell lymphoma cells, affecting anti-CD37 therapy efficacy, but not CAR-T cell effectiveness.