Takeshi Shimosato

This study shows that iSN40, a CpG-ODN, inhibits osteoclast formation via TLR9-dependent mechanisms and may be a therapeutic for osteoporosis.

The paper shows that the anti-nucleolin aptamer iSN04 inhibits vascular smooth muscle cell proliferation and promotes differentiation, suggesting it as a potential therapy for vascular disease.

This paper develops a 12-base myogenetic oligodeoxynucleotide that maintains the myogenic activity of a longer sequence while improving drug efficacy and synthesis cost.

This study shows that the myogenetic oligodeoxynucleotide iSN04 induces cardiomyocyte differentiation from murine pluripotent stem cells by modulating Wnt signaling and inhibiting nucleolin.