Laurent Blanchoin

The paper investigates how actin networks scale with cell volume by reconstituting dynamic structures in controlled environments and shows that monomer depletion and disassembly rates determine scaling behavior.

The paper measures microtubule turnover and PTMs in mouse cells, finding that PTMs do not accumulate with age or correlate with stability.

This study shows that contractile forces in endothelial cell pairs determine the direction and strength of chiral swirling in minimal cell collectives.

The paper describes the fabrication of microwells for encapsulating active matter, enabling controlled studies of cytoskeleton dynamics and other cellular processes.

This study shows AML blasts fail to polarize when interacting with healthy stromal cells, and AML-derived stromal cells impair polarization of healthy HSPCs and AML blasts.

The paper shows centrosome positioning is driven by actomyosin contractile networks and cell shape remodeling, not microtubule-based forces.

This study shows that actin network contractile steady states can be sustained by filament transport rather than assembly/disassembly in an in vitro system.

This study investigates how actin networks coexist under resource competition by using a reconstituted system, showing that protein turnover enables coexistence but intense competition favors stronger networks.

This study shows that interaction with osteoblasts promotes asymmetric division of human HSPCs, leading to unequal inheritance of lysosomes and differentiation markers.

The paper identifies plakins as regulators of epithelial polarity by showing their downregulation in polarity loss and EMT progression, and demonstrates their causal role through experimental knockdown.

This study develops a biophysical model of actin filament bundles to determine optimal conditions for mechanical power generation under external forces.