Author

Srinivas Vinod Saladi

Broad InstituteORCID 0000-0001-8147-4379Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Avinash WaghrayiD· 2 shared Brian LiniD· 2 shared Jayaraj RajagopaliD· 2 shared Mateo UsecheiD· 2 shared Abdullah Al EmraniD· 1 shared Alexander M. TsankoviD· 1 shared Amritha G Prabha· 1 shared Aviv RegeviD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Avinash WaghrayORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 10, 2025

YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programs

Nana Chen, Gracia M. Bonilla, Abdullah Al Emran…·Srinivas Vinod Saladi

This paper shows YAP1 promotes therapy resistance in melanoma by altering chromatin structure and immune evasion programs, and suggests TEAD inhibitors could overcome resistance and boost immune response.

DOI 10.1101/2025.09.10.675381

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJul 2, 2024

Impact of PI3K pathway alterations on response to immune checkpoint inhibitors in HPV-negative head and neck squamous cell carcinoma

Jong Chul Park, Nandini Pal Basak, Mateo Useche…·Srinivas Vinod Saladi

This study shows that PI3K pathway alterations in HPV-negative HNSCC are linked to poor outcomes and immune suppression, and that inhibiting PI3K can enhance immune response.

1 citation

humanbulk RNA-seq

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Cell BiologybioRxivPreprintNov 28, 2023

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

Avinash Waghray, Isha Monga, Brian Lin…·Jayaraj Rajagopal

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

15 citations

humanscRNA-seq

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