Cancer BiologyMolecular CancerPeer-reviewed
The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
William J. McDaid, L. Wilson, Helen Adderley…·Angeliki Malliri
This study compares KRASG12C and KRASG12D mutant NSCLC models, finding that KRASG12D relies more on the PI3K-AKT-mTOR pathway, suggesting tailored combination therapies.
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