Author

Shengwei Wu

Koch Institute for Integrative Cancer Research At MITORCID 0000-0001-8175-3490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Darrell J. IrvineiD· 3 shared Heikyung SuhiD· 2 shared Aereas AungiD· 1 shared Amir LedbetteriD· 1 shared Andrew J. PickeringiD· 1 shared Anika WadheraiD· 1 shared Anna M. RomanoviD· 1 shared Apoorv ShankeriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBioengineering

Darrell J. IrvineORCID

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3 papers

Recent·Most cited

BioengineeringNature MaterialsPeer-reviewedOct 31, 2025

'Target-and-release' nanoparticles for effective immunotherapy of metastatic ovarian cancer

Ivan Susin Pires, Gil Covarrubias, Victoria F. Gomerdinger…·Paula Therese Hammond

This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.

28 citationstop 2%

mouseexperimental assay

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BioengineeringbioRxivPreprintJun 8, 2025

Engineering gene expression dynamics via self-amplifying RNA with drug-responsive non-structural proteins

Parisa Yousefpour, Justin R. Gregory, Kristen Si…·Darrell J. Irvine

This paper designs a drug-regulated gene expression system using self-amplifying RNA with TMP-responsive degradation domains, showing enhanced immune responses in mice.

7 citations

mouseexperimental assay

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ImmunologyScience ImmunologyPeer-reviewedSep 20, 2024

Two-dose "extended priming" immunization amplifies humoral immune responses by synchronizing vaccine delivery with the germinal center response

Sachin H. Bhagchandani, Leerang Yang, Jonathan H. Lam…·Darrell J. Irvine

This study shows that a two-dose extended priming vaccine regimen enhances humoral immune responses by synchronizing antigen delivery with germinal center dynamics.

39 citationstop 3%

proteomicsexperimental assay

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