Santiago F. Elena

This study shows Orsay virus infection reduces locomotion in C. elegans and alters food choice based on sensory context, with eol-1 modulating these behaviors.

This study shows latent viruses can alter disease severity and viral accumulation in plant coinfections, with outcomes depending on host and viral genotypes.

The paper characterizes replication dynamics and short-term evolutionary patterns of OrV, revealing strand asymmetry, mutational filtering, and non-standard genomes.

The paper uses cryo-EM to study Orsay virus structure, revealing stochastic genome assortment and segment-specific replication dynamics in virion assembly.

This study examines how simulated microgravity affects the short-term evolutionary trajectories of Orsay virus in C. elegans, finding modest phenotypic changes and no significant virulence shifts.

The paper maps eco-evolutionary barriers to Orsay virus host range across six Caenorhabditis species by analyzing viral life cycle dynamics and host competence phenotypes.

This study examines how reduced gravity and muon flux affect viral infection and life history traits in Caenorhabditis elegans, revealing impacts on reproduction, morphology, and viral dynamics.

This study evolves a plant RNA virus in age-diverse host populations and finds that host age structure drives virulence evolution by shaping disease progression, severity, and viral load.

This study examines how simulated space conditions affect viral infection in C. elegans, finding that abiotic stressors reduce viral replication and alter host gene expression.

This study investigates how Orsay virus infection affects Caenorhabditis elegans larval development and how molting periods influence viral replication.

This study examines how host replacement dynamics influence virulence and genome evolution in a plant RNA virus, showing that sudden transitions lead to faster virulence changes and more severe symptoms.

This study identifies HSP70 homologs in diverse viruses, revealing multiple evolutionary origins and functional adaptations.

This study examines how host changes affect viral evolution by analyzing allele frequency dynamics and finding that Taylor's power law governs mutation distribution during host replacement.

This study investigates how chronic Orsay virus infection in C. elegans leads to age-dependent immunity and superinfection exclusion.

The paper analyzes SARS-CoV-2 infected cell gene expression dynamics using statistical methods, finding biphasic patterns and gene-specific stability/dependence behaviors.

The paper presents a method to quantify defective and wild-type viral genomes from RNA-seq data by analyzing depth deviations, providing whole-genome estimates of their proportions.

The paper investigates how epigenetic modifications in Arabidopsis thaliana affect the evolution of Turnip Mosaic Virus, identifying gene expression patterns and viral targets.

This study tracks the progression of OrV infection in C. elegans, identifying four infection stages and gene expression changes, revealing virus-specific and general immune responses.

This study investigates age-dependent susceptibility to viral infections in Arabidopsis thaliana, finding that later stages show increased viral spread but also greater fertility, suggesting a trade-off between susceptibility and fitness.

This study shows that Orsay virus infection increases Caenorhabditis elegans resistance to heat shock through upregulation of argonaute proteins, suggesting a mutualistic relationship under thermal stress.

This paper describes an efficient plasmid-based system for producing recombinant VSV encoding foreign glycoproteins, validated with glycoproteins from multiple viral families.

This study evolves two Orsay virus strains in C. elegans, finding slight infectivity changes, non-synonymous mutations, and non-random distribution of minor variants in polymorphic regions.

This study analyzes viromes across 31 invertebrate phyla using RNA-Seq data to estimate virome composition, quantify diversity, and assess host and habitat influences on virome structure.

This study tracks defective viral genome (DVG) dynamics in two betacoronaviruses under different MOI conditions, showing increased diversity and abundance with specific deletion patterns.

This study shows how SARS-CoV-2 spike protein adapts to different human cell types through mutations that affect entry efficiency and receptor affinity.

The paper investigates how mutations in TuMV's VPg protein affect its interactions with host proteins in Arabidopsis thaliana, revealing their impact on viral adaptation and plant tolerance.

The paper identifies a genetic region associated with systemic necrosis in Arabidopsis thaliana infected with turnip mosaic virus, showing a trade-off between resistance and fitness costs.

The paper reanalyzes scRNA-seq data from infected human cells to identify a triphasic transcriptional response to SARS-CoV-2 infection, revealing three distinct up- and down-regulatory phases.

The paper uses scRNA-seq to compare how two viruses affect enteroendocrine cells in Drosophila, showing subtype-specific replication strategies and gene expression changes.

The paper analyzes viral replication modes using a dynamical systems approach to determine critical mutation rates for lethal mutagenesis and error catastrophe in different replication strategies.