Rafael Sanjuán

The paper identifies entry inhibitors against emerging viruses using a phylogenetic framework, finding drugs with broad antiviral activity across related viral RBPs.

This study shows that sialic acids restrict entry of non-influenza orthomyxoviruses, unlike influenza viruses, and identifies mutations that can overcome this restriction.

This study shows that phenotypic heterogeneity in Klebsiella pneumoniae affects phage resistance and cocktail efficacy, with acapsular variants being more susceptible to phages and sustaining cocktail effectiveness under selective pressure.

This study identifies dipeptidase 1 as the receptor for PHEV, showing it does not require sialic acid and reveals structural versatility in receptor binding.

This paper models phage depolymerase capsular tropism using graph neural networks and sequence clustering, showing predictive ability and transferability to lytic phages.

The paper identifies a novel torovirus in a dormouse, suggesting rodents may be a reservoir for toroviruses and highlighting their potential for cross-species transmission.

This study measures the mutation rate of phage lambda and finds it is higher than its host E. coli but not significantly increased by MMR inactivation.

This study identifies six novel bat coronaviruses in Spain, three of which are potentially new species, and finds one can use human ACE2 receptor, indicating zoonotic potential.

This study uses experimental evolution to identify mutations in the SADS-CoV spike protein that enhance its ability to infect human cells, potentially increasing its zoonotic potential.

The paper shows that Klebsiella pneumoniae can resist phage infection through reversible downregulation of capsule biosynthesis without genetic mutations.

The paper experimentally tests the ability of viral receptor-binding proteins from 100+ enveloped RNA viruses to enter human cells, finding that most can do so, with variation among families and host factors playing a role.

The paper identifies 25 complete or near-complete DNA virus genomes from small terrestrial mammals in Spain, including 18 potential new species or types.

The paper isolates and characterizes phages targeting Klebsiella pneumoniae clinical isolates, showing that specific phage hunting is more effective than broad-spectrum approaches for infection control.

The paper identifies new picornaviruses from Spanish bats, including a potential plant host calhevirus, highlighting their geographic distribution and interspecies transmissibility.

DepoScope uses large language models to accurately annotate phage depolymerases and their domains, improving detection through sequence and amino-acid level predictions.

The paper describes a new pararetrovirus found in an insectivorous bat, which forms a basal clade distinct from hepadnaviruses and nackednaviruses, suggesting ancestral non-enveloped pararetroviruses.

The paper uses viral metagenomics to analyze bat fecal samples, identifying 50 complete or near-complete DNA virus genomes, including 28 potential new species, expanding the known European DNA virus diversity.

This paper describes an efficient plasmid-based system for producing recombinant VSV encoding foreign glycoproteins, validated with glycoproteins from multiple viral families.

This study shows that temperature affects SARS-CoV-2 spike fusogenicity and evolution, with higher temperatures increasing fusion and specific mutations showing temperature-dependent effects.

This study shows how SARS-CoV-2 spike protein adapts to different human cell types through mutations that affect entry efficiency and receptor affinity.