Oonagh Shannon

This study examines temporal changes in platelet activation and organ dysfunction during invasive Streptococcus pyogenes infection in mice, showing platelets contribute to liver dysfunction and may be therapeutic targets.

This paper designs an epitope-centric nanoparticle vaccine against Streptococcus pyogenes using structural mass spectrometry and deep learning to enhance immunogenicity.

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

This study uses pharmacoproteomics to analyze treatment responses in a murine sepsis model, identifying distinct response patterns and drug interactions across organs and time.