Justin P. Annes

This study identifies ABCB1 silencing in SDHB-deficient cancers and shows that vincristine improves progression-free survival in SDHB-mutant PPGL patients.

The paper identifies CD38 as a marker for pathogenic T cells in T1D and shows that anti-CD38 mAb selectively depletes these cells to prevent diabetes without affecting Tregs.

This paper shows SDHB-deficient cancer cells are more sensitive to Ym155-induced DNA damage due to impaired DNA repair and succinate accumulation.

The paper identifies the serotonin 1F receptor as a negative regulator of human beta cell survival during transplant and demonstrates a small molecule antagonist that improves glycemia in islet transplants.

This paper develops a β-cell-based platform for on-demand recombinant protein delivery by modifying the endogenous insulin processing pathway to produce and release therapeutic peptides like GLP-1 or glucagon.

Applying sub-minute pressure at physiological levels enhances therapeutic insulin transport from macroencapsulated islets, enabling rapid glucose regulation in diabetic rodent models.