Fernando José Santos Rodrigues

This study overexpresses paracoccin (PCN) in Paracoccidioides brasiliensis and finds that increased PCN levels enhance chitin hydrolysis, leading to smaller chitin particles that modulate host immune responses and increase fungal virulence.

This study identifies five types of genetic variation in secondary metabolic gene clusters across 66 strains of Aspergillus fumigatus and links them to evolutionary drivers like mutation, recombination, and horizontal gene transfer.