Robin W. Yeo

The paper introduces casmini-tool, a database for designing dCasMINI guide RNAs with off-target prediction and PAM profile analysis for CRISPRi/a applications.

The paper investigates chromatin accessibility changes in neurogenic niche cells during aging, identifying defects in NSC adhesion and migration and proposing ROCK inhibition as a potential therapeutic strategy.

The paper identifies compact CRISPR-based activators with durable gene activation, improving upon existing tools in potency and persistence.

This paper improves few-shot learning for protein engineering by combining transfer learning and evolutionary sampling, achieving better hit rates in experimental testing.

The paper investigates how male sexual interactions negatively affect female and hermaphrodite lifespan in C. elegans, uncovering genes involved in male-induced demise and longevity pathways.

The paper uses CRISPR-Cas9 screens in vitro and in vivo to identify gene knockouts that enhance neural stem cell activation in aged mice, finding that GLUT4 knockout is a top rejuvenating intervention.

This study uses ATAC-seq in C. elegans to identify dynamic chromatin accessibility changes, revealing novel enhancers and a regulatory factor involved in development.