NeurosciencebioRxivPreprint
In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain
Tyson Joel Ruetz, Chloe M. Kashiwagi, Bhek Morton…·Anne Brunet
The paper uses CRISPR-Cas9 screens in vitro and in vivo to identify gene knockouts that enhance neural stem cell activation in aged mice, finding that GLUT4 knockout is a top rejuvenating intervention.
6 citations