Shuai Wang

This study shows SARS-CoV-2 RdRp can use NDPs and MDP to incorporate NHC into RNA, with MDP being a better substrate than MTP.

The paper identifies and engineers a compact SlugCas9 variant with broad targeting range, high specificity, and activity for genome editing.

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.